Attenuated β-adrenergic response in calcium/calmodulin-dependent protein kinase IV-knockout mice

April 23, 2021 Leave a comment
Within the current research, we examined the significance of Ca2+/calmodulin-dependent protein kinase IV (CaMKIV) within the regulation of cardiac operate utilizing genetically modified CaMKIV-null mice. RT-PCR evaluation revealed decreased expression of voltage-dependent calcium channels within the cardiac myocytes of CaMKIV-null mice in contrast with wild-type mice. CaMKIV-null mice confirmed shortened QT time on electrocardiograms.
Pharmacological evaluation revealed decreased responsiveness to the β-adrenergic blocker propranolol in CaMKIV-null mice, whereas the plasma norepinephrine degree was not affected. CaMKIV-null mice confirmed decreased baroreflex on electrocardiograms. Coronary heart price variability evaluation confirmed unstable R-R intervals, a decreased low frequency energy/excessive frequency energy (LF/HF) ratio, and elevated normal deviation of the conventional to regular R-R intervals (SDNN) in CaMKIV-null mice, suggesting decreased responsiveness to β-adrenergic stimulation in CaMKIV-null mice.
Atrial contraction evaluation and cardiac motion potential recording confirmed a decreased response to the β-adrenoceptor agonist isoproterenol in CaMKIV-null mice. Moreover, fluorescence imaging in a CRE-hrGFP assay revealed a decreased response to isoproterenol in CaMKIV-null cardiac myocytes. Taken collectively, our information strongly counsel a big impact of CaMKIV gene ablation on cardiac β-adrenergic sign transduction.

Protein kinase PIM2: A easy PIM household kinase with complicated features in most cancers metabolism and therapeutics

PIM2 (proviral integration website for Moloney murine leukemia virus 2) kinase performs an vital function as an oncogene in a number of cancers, equivalent to leukemia, liver, lung, myeloma, prostate and breast cancers. PIM2 is essentially expressed in each leukemia and strong tumors, and it promotes the transcriptional activation of genes concerned in cell survival, cell proliferation, and cell-cycle development.
Many tumorigenic signaling molecules have been recognized as substrates for PIM2 kinase, and a wide range of inhibitors have been developed for its kinase exercise, together with SMI-4a, SMI-16a, SGI-1776, JP11646 and DHPCC-9. Right here, we summarize the signaling pathways concerned in PIM2 kinase regulation and PIM2 mechanisms in varied neoplastic ailments. We additionally talk about the present standing and future views for the event of PIM2 kinase inhibitors to fight human most cancers, and PIM2 will grow to be a therapeutic goal in cancers sooner or later.

Cyclic AMP-dependent protein kinase reveals antagonistic results on the replication effectivity of various HPV sorts

A number of forms of widespread human papillomaviruses (HPVs) could induce transformation of contaminated cells, scary the event of neoplasms. Two foremost genera of HPVs are categorized as mucosatropic α and cutaneotropic β HPVs, they usually each embody high-risk cancer-associated species. The absence of antiviral medicine has pushed investigations into the main points of the molecular mechanisms of the HPV life cycle. HPV replication is determined by viral helicase E1 and transcription issue E2. Their organic actions are managed by quite a few mobile proteins, together with protein kinases.
Right here, we report that ubiquitously expressed cyclic A
MP-dependent protein kinase A (PKA) differentially regulates the replication of α HPV11, α HPV18 and β HPV5. PKA stimulates the replication of each α HPVs studied however has a extra profound impact on the replication of high-risk α HPV18. Nevertheless, replication of β HPV5 is inhibited by activated PKA in human major keratinocytes and U2OS cells. We present that activation of PKA signaling by totally different pharmacological brokers induces speedy proteasomal degradation of the HPV5 E2 protein, which in flip results in the downregulation of E2-dependent transcription. In distinction, PKA-stimulated induction of HPV18 replication is the results of the downregulation of the E8^E2 transcript coding a potent viral transcriptional inhibitor along with speedy upregulation of E1 and E2 protein ranges.
IMPORTANCEA number of forms of human papillomaviruses (HPVs) are causative brokers of assorted forms of epithelial cancers. Right here, we report that ubiquitously expressed cyclic AMP-dependent protein kinase A (PKA) differentially regulates the replication of assorted forms of HPVs throughout the preliminary amplification and upkeep phases of the viral life cycle. Replication of the pores and skin cancer-related pathogen HPV5 is suppressed, whereas replication of the cervical cancer-associated HPV18 is activated in response to elevated PKA exercise.
Attenuated β-adrenergic response in calcium/calmodulin-dependent protein kinase IV-knockout mice
To inhibit HPV5 replication, PKA targets the viral transcriptional activator E2, inducing its speedy proteasomal degradation. PKA-dependent stimulation of HPV18 replication depends on the downregulation of one other E2 gene product, E8^E2, which encodes a potent transcriptional repressor. Our findings spotlight, for the primary time, protein kinase-related mechanistic variations within the regulation of the replication of mucosal and cutaneous HPV sorts.

Interaction Between CMGC Kinases Concentrating on SR Proteins and Viral Replication: Splicing and Past

Protein phosphorylation constitutes a serious post-translational modification that critically regulates the half-life, intra-cellular distribution, and exercise of proteins. Among the many giant variety of kinases that compose the human kinome tree, these focusing on RNA-binding proteins, specifically serine/arginine-rich (SR) proteins, play a serious function within the regulation of gene expression by controlling constitutive and various splicing. In people, these kinases belong to the CMGC [Cyclin-dependent kinases (CDKs), Mitogen-activated protein kinases (MAPKs), Glycogen synthase kinases (GSKs), and Cdc2-like kinases (CLKs)] group and several other research point out that in addition they management viral replication by way of direct or oblique mechanisms.

Human Follistatin Like Protein 1 ELISA kit
E01F0385-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Follistatin Like Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Follistatin Like Protein 1 ELISA kit
E01F0385-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Follistatin Like Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Follistatin Like Protein 1 ELISA kit
E01F0385-96 1 plate of 96 wells
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Description: A competitive ELISA for quantitative measurement of Human Follistatin Like Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Follistatin Like Protein 1 (FSTL1) CLIA Kit
abx195666-96tests 96 tests
EUR 990

Human Follistatin Like Protein 1 (FSTL1) CLIA Kit
20-abx495609
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Human Follistatin Like Protein 1 (FSTL1) CLIA Kit
20-abx496349
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  • 96 tests

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
20-abx151593
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  • 96 tests

Human Follistatin Like Protein 1 (FSTL1)ELISA Kit
201-12-2703 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
abx250695-96tests 96 tests
EUR 801.6

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
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Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
20-abx258761
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  • 10 × 96 tests
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  • 96 tests

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
DLR-FSTL1-Hu 96T
EUR 463
Description: serum, plasma or other biological fluids.

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
DLR-FSTL1-Hu-48T 48T
EUR 620.4
Description: A sandwich quantitative ELISA assay kit for detection of Human Follistatin Like Protein 1 (FSTL1) in samples from serum, plasma or other biological fluids.

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
DLR-FSTL1-Hu-96T 96T
EUR 807.6
Description: A sandwich quantitative ELISA assay kit for detection of Human Follistatin Like Protein 1 (FSTL1) in samples from serum, plasma or other biological fluids.

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
EKL57365-5x96T 5x96T
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EKL57365-96T 96T
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EK714392 96 Wells
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Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
EKN45366-96T 96T
EUR 541

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
DL-FSTL1-Hu 96T
EUR 441
Description: serum, plasma or other biological fluids.

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
EK12104 96Т
EUR 799

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
AE63088HU-48Tests 48 Tests
EUR 360
Description: Human (Homo sapiens)

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
AE63088HU-96Tests 96 Tests
EUR 680
Description: Human (Homo sapiens)

Human Follistatin Like Protein 1(FSTL1) ELISA Kit
CSB-E13516h-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Follistatin Like Protein 1 (FSTL1) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Follistatin Like Protein 1(FSTL1) ELISA Kit
1-CSB-E13516h
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  • 1 plate of 96 wells
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Description: Quantitativesandwich ELISA kit for measuring Human Follistatin Like Protein 1(FSTL1) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
EKN51659-48T 48T
EUR 328.44

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EKN51659-5x96T 5x96T
EUR 2228.7

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
EKN51659-96T 96T
EUR 469.2

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
RK10870 96T
EUR 280

Human Follistatin Like Protein 1 ELISA Kit (FSTL1)
RK01421 96 Tests
EUR 625.2

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QY-E02219 96T
EUR 433.2

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
RDR-FSTL1-Hu-48T 48T
EUR 475.34
Description: serum, plasma and other biological fluids.

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
RDR-FSTL1-Hu-48Tests 48 Tests
EUR 652.8

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
RDR-FSTL1-Hu-96T 96T
EUR 679.04
Description: serum, plasma and other biological fluids.

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
RDR-FSTL1-Hu-96Tests 96 Tests
EUR 907.2

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
RD-FSTL1-Hu-48T 48T
EUR 452.7
Description: serum, plasma and other biological fluids.

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
RD-FSTL1-Hu-48Tests 48 Tests
EUR 625.2

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
RD-FSTL1-Hu-96T 96T
EUR 646.7
Description: serum, plasma and other biological fluids.

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
RD-FSTL1-Hu-96Tests 96 Tests
EUR 867.6

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
SEJ085Hu-10x96wellstestplate 10x96-wells test plate
EUR 5677.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Follistatin Like Protein 1 (FSTL1) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
SEJ085Hu-1x48wellstestplate 1x48-wells test plate
EUR 572.76
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Follistatin Like Protein 1 (FSTL1) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
SEJ085Hu-1x96wellstestplate 1x96-wells test plate
EUR 766.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Follistatin Like Protein 1 (FSTL1) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
SEJ085Hu-5x96wellstestplate 5x96-wells test plate
EUR 3090.6
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Follistatin Like Protein 1 (FSTL1) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
4-SEJ085Hu
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Follistatin Like Protein 1 (FSTL1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Follistatin Like Protein 1 (FSTL1)ELISA Kit
YLA3342HU-48T 48T Ask for price

Human Follistatin Like Protein 1 (FSTL1)ELISA Kit
YLA3342HU-96T 96T Ask for price

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
abx258761-1mg 1 mg
EUR 5962.5

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
abx258761-20g 20 µg
EUR 3150

Human Follistatin Like Protein 1 (FSTL1) ELISA Kit
abx258761-5g 5 µg
EUR 662.5

Human FSTL1 -Follistatin Like Protein 1- CLIA Kit
E-CL-H0158-24Tests 24 Tests
EUR 180
Description: Sandwich

Human FSTL1 -Follistatin Like Protein 1- CLIA Kit
E-CL-H0158-48Tests 48 Tests
EUR 546
Description: Sandwich

Human FSTL1 -Follistatin Like Protein 1- CLIA Kit
E-CL-H0158-96Tests 96 Tests
EUR 682
Description: Sandwich

Human FSTL1 -Follistatin Like Protein 1- CLIA Kit
E-CL-H0158-96Tests10 96 Tests *10
EUR 6820
Description: Sandwich

Human FSTL1 -Follistatin Like Protein 1- CLIA Kit
E-CL-H0158-96Tests5 96 Tests *5
EUR 3410
Description: Sandwich

Human FSTL1 (Follistatin Like Protein 1) ELISA Kit
EKE60147-5x96T 5x96T
EUR 3124.08

Human FSTL1 (Follistatin Like Protein 1) ELISA Kit
EKE60147-96T 96T
EUR 657.7

Human FSTL1(Follistatin Like Protein 1) ELISA Kit
ELK3142-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human FSTL1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human FSTL1. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human FSTL1, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human FSTL1 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human FSTL1(Follistatin Like Protein 1) ELISA Kit
ELK3142-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human FSTL1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human FSTL1. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human FSTL1, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human FSTL1 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human FSTL1(Follistatin Like Protein 1) ELISA Kit
RE1085H-48wells 48 wells
EUR 116.55

Human FSTL1(Follistatin Like Protein 1) ELISA Kit
RE1085H-96wells 96 wells
EUR 161.55

Human Follistatin Like Protein 3 ELISA kit
E01A4602 96T
EUR 700
Description: ELISA

Human Follistatin Like Protein 3 ELISA kit
E01F0387-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Follistatin Like Protein 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Follistatin Like Protein 3 ELISA kit
E01F0387-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Follistatin Like Protein 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Follistatin Like Protein 3 ELISA kit
E01F0387-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Follistatin Like Protein 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Follistatin Like Protein 1 (FSTL1) Antibody
20-abx112569
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  • 150 ul
  • 50 ul

Follistatin Like Protein 1 (FSTL1) Antibody
20-abx102738
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Follistatin Like Protein 1 (FSTL1) Antibody
20-abx102739
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  • 100 ug
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  • 1 mg
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Follistatin Like Protein 1 (FSTL1) Antibody
20-abx131049
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Follistatin Like Protein 1 (FSTL1) Antibody
abx122504-100ug 100 ug
EUR 469.2

Follistatin Like Protein 1 (FSTL1) Antibody
abx025769-400ul 400 ul
EUR 627.6

Follistatin Like Protein 1 (FSTL1) Antibody
abx025769-80l 80 µl
EUR 343.2

Follistatin Like Protein 1 (FSTL1) Antibody
abx233232-100ug 100 ug
EUR 577.2

Follistatin Like Protein 1 (FSTL1) Antibody
20-abx172459
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  • 100 ug
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Follistatin Like Protein 1 (FSTL1) Antibody
20-abx172460
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  • 1 mg
  • 200 ug

Follistatin Like Protein 1 (FSTL1) Antibody
abx432716-200ul 200 ul
EUR 460.8

Follistatin Like Protein 1 (FSTL1) Antibody
20-abx241524
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  • 100 ul
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Follistatin Like Protein 1 (FSTL1) Antibody
20-abx241525
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  • 100 ul
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Follistatin Like Protein 1 (FSTL1) Antibody
20-abx313310
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  • 100 ug
  • 1 mg
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Follistatin Like Protein 1 (FSTL1) Antibody
abx102738-100l 100 µl
EUR 287.5

Follistatin Like Protein 1 (FSTL1) Antibody
abx102738-1ml 1 ml
EUR 812.5

Follistatin Like Protein 1 (FSTL1) Antibody
abx102738-200l 200 µl
EUR 362.5

Follistatin Like Protein 1 (FSTL1) Antibody
abx102739-100l 100 µl
EUR 312.5

Follistatin Like Protein 1 (FSTL1) Antibody
abx102739-1ml 1 ml
EUR 962.5

Follistatin Like Protein 1 (FSTL1) Antibody
abx102739-200l 200 µl
EUR 400

Follistatin Like Protein 1 (FSTL1) Antibody
abx172459-100l 100 µl
EUR 275

Follistatin Like Protein 1 (FSTL1) Antibody
abx172459-1ml 1 ml
EUR 787.5

Follistatin Like Protein 1 (FSTL1) Antibody
abx172459-200l 200 µl
EUR 350

Follistatin Like Protein 1 (FSTL1) Antibody
abx172460-100l 100 µl
EUR 850

Follistatin Like Protein 1 (FSTL1) Antibody
abx172460-1ml 1 ml Ask for price

Follistatin Like Protein 1 (FSTL1) Antibody
abx172460-200l 200 µl Ask for price

Follistatin Like Protein 1 (FSTL1) Antibody
abx112569-100l 100 µl
EUR 612.5

Follistatin Like Protein 1 (FSTL1) Antibody
abx122504-100l 100 µl Ask for price

Follistatin Like Protein 1 (FSTL1) Antibody
abx122504-20l 20 µl
EUR 337.5

Follistatin Like Protein 1 (FSTL1) Antibody
abx122504-50l 50 µl Ask for price

Follistatin Like Protein 1 (FSTL1) Antibody
abx025769-400l 400 µl
EUR 518.75

Follistatin Like Protein 1 (FSTL1) Antibody
abx241524-100g 100 µg
EUR 350

Follistatin Like Protein 1 (FSTL1) Antibody
abx241524-10g 10 µg
EUR 250

Follistatin Like Protein 1 (FSTL1) Antibody
abx241524-200g 200 µg Ask for price

Follistatin Like Protein 1 (FSTL1) Antibody
abx241525-100g 100 µg
EUR 350

Follistatin Like Protein 1 (FSTL1) Antibody
abx241525-10g 10 µg
EUR 250

Follistatin Like Protein 1 (FSTL1) Antibody
abx241525-200g 200 µg Ask for price

Follistatin Like Protein 1 (FSTL1) Antibody
abx131049-100l 100 µl
EUR 750

Follistatin Like Protein 1 (FSTL1) Antibody
abx131049-20l 20 µl
EUR 275

Follistatin Like Protein 1 (FSTL1) Antibody
abx131049-50l 50 µl
EUR 337.5

Follistatin Like Protein 1 (FSTL1) Antibody
abx233232-100g 100 µg
EUR 350

Follistatin Like Protein 1 (FSTL1) Antibody
abx313310-100g 100 µg
EUR 362.5

Follistatin Like Protein 1 (FSTL1) Antibody
abx313310-20g 20 µg
EUR 162.5

Follistatin Like Protein 1 (FSTL1) Antibody
abx313310-50g 50 µg
EUR 250

Follistatin Like Protein 1 (FSTL1) Antibody
abx432716-100g 100 µg
EUR 387.5

Human Follistatin Like Protein 1, FSTL1 GENLISA ELISA
KBH2702 1 x 96 wells
EUR 286

Follistatin Like Protein 1 (FSTL1) Monoclonal Antibody (Human)
4-MAJ085Hu21
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Follistatin Like Protein 1 (FSTL1)

ELISA kit for Human Follistatin Like Protein 1 (FSTL1)
KTE62635-48T 48T
EUR 424.8
Description: Quantitative sandwich ELISA for measuring Human Follistatin Like Protein 1 (FSTL1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Follistatin Like Protein 1 (FSTL1)
KTE62635-5platesof96wells 5 plates of 96 wells
EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Human Follistatin Like Protein 1 (FSTL1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Follistatin Like Protein 1 (FSTL1)
KTE62635-96T 96T
EUR 686.4
Description: Quantitative sandwich ELISA for measuring Human Follistatin Like Protein 1 (FSTL1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

CLIA kit for Human FSTL1 (Follistatin Like Protein 1)
E-CL-H0158 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Human FSTL1 (Follistatin Like Protein 1) in samples from Serum, Plasma, Cell supernatant

FSTL1 Follistatin Like 1 Human Recombinant Protein
PROTQ12841 Regular: 10ug
EUR 380.4
Description: FSTL1 Human Recombinant produced in E. coli is a single polypeptide chain containing 309 amino acids (21-308) and having a molecular mass of 34.9 kDa.;FSTL1 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

ELISA kit for Human FSTL1 (Follistatin Like Protein 1)
E-EL-H0173 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human FSTL1 (Follistatin Like Protein 1) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human FSTL1 (Follistatin Like Protein 1)
ELK3142 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Follistatin Like Protein 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Rat Follistatin Like Protein 1 (FSTL1) Protein
20-abx066685
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Rat Follistatin Like Protein 1 (FSTL1) Protein
abx066685-5mg 5 mg
EUR 387.5

Follistatin Like Protein 1 (FSTL1) Monoclonal Antibody (Human), PE
4-MAJ085Hu21-PE
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Follistatin Like Protein 1 (FSTL1). This antibody is labeled with PE.

Follistatin Like Protein 1 (FSTL1) Antibody (HRP)
20-abx313311
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Follistatin Like Protein 1 (FSTL1) Antibody (HRP)
abx313311-100g 100 µg
EUR 362.5

Follistatin Like Protein 1 (FSTL1) Antibody (HRP)
abx313311-20g 20 µg
EUR 162.5

Follistatin Like Protein 1 (FSTL1) Antibody (HRP)
abx313311-50g 50 µg
EUR 250

Human Follistatin Like Protein 3 (FSTL3) ELISA Kit
abx250652-96tests 96 tests
EUR 801.6

Follistatin Like Protein 1 (FSTL1) Polyclonal Antibody (Human, Pig)
4-PAJ085Hu01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Pig Follistatin Like Protein 1 (FSTL1)

Follistatin Like Protein 1 (FSTL1) Monoclonal Antibody (Human), APC
4-MAJ085Hu21-APC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Follistatin Like Protein 1 (FSTL1). This antibody is labeled with APC.

Follistatin Like Protein 1 (FSTL1) Monoclonal Antibody (Human), Cy3
4-MAJ085Hu21-Cy3
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Follistatin Like Protein 1 (FSTL1). This antibody is labeled with Cy3.

Follistatin Like Protein 1 (FSTL1) Monoclonal Antibody (Human), HRP
4-MAJ085Hu21-HRP
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Follistatin Like Protein 1 (FSTL1). This antibody is labeled with HRP.

Human Follistatin like-protein 1/FSTL1 Recombinant Protein
100-437 50 µg
EUR 196.35
Description: Follistatin-like protein 1 (FSTL1) is a widely-expressed, extracellular glycoprotein that is homologously grouped into the osteonectin (BM-40/SPARC) family of secreted proteins based on its possession of both a follistatin-like and extracellular calcium-binding domain. Initially identified as a TGF-beta-inducible protein in a cloned mouse osteoblast cell line, FSTL1 has since been implicated in an array of cell-type-specific functions, such as the regulation of proliferation, differentiation, apoptosis and migration, as well as a number of biological processes, including embryonic development, inflammatory response, angiogenesis, tumorigenesis, and immune disease pathogenesis. Highly conserved across mammalian species and widely expressed in human tissues, FSTL1 can be upregulated through signaling mediators of the innate immune system, such as TLR4 agonists and the arthritogenic cytokine IL-1beta via NFκB pathways, to stimulate the expression and secretion of pro-inflammatory cytokines, including TNF-alpha, IL-1beta, IL-6 and IL-8. While cells of mesenchymal lineage are capable of FSTL1 production, FSTL1 expression is notably absent from cells of hematopoietic lineage under normal physiological conditions. Macrophages and monocytes are, however, capable of taking up FSTL1 at sites of inflammation where FSTL1 stimulation can cause the expression of caspase-1 and its resultant enzymatic cleavage of active IL-1beta from pro-IL-1beta. Whereas the overexpression of FSTL1 has been noted as a substantial contributor to the progression of immune diseases like rheumatoid arthritis (RA) and osteoarthritis (OA), diminished FSTL1 serum levels have been identified as playing a significant part in both ovarian and endometrial carcinogenesis, where it directly affects cell proliferation, migration and invasion. The CHO cell-derived recombinant human FSTL1 is a 288-amino-acid-length glycoprotein with a calculated molecular weight of 32.7 kDa; however, due to glycosylation, protein migration occurs at an apparent molecular weight of approximately 50-55 kDa by SDS-PAGE analysis under both reducing and non-reducing conditions.

Human Follistatin like-protein 1/FSTL1 Recombinant Protein
100-437S 10 µg
EUR 92.4
Description: Follistatin-like protein 1 (FSTL1) is a widely-expressed, extracellular glycoprotein that is homologously grouped into the osteonectin (BM-40/SPARC) family of secreted proteins based on its possession of both a follistatin-like and extracellular calcium-binding domain. Initially identified as a TGF-beta-inducible protein in a cloned mouse osteoblast cell line, FSTL1 has since been implicated in an array of cell-type-specific functions, such as the regulation of proliferation, differentiation, apoptosis and migration, as well as a number of biological processes, including embryonic development, inflammatory response, angiogenesis, tumorigenesis, and immune disease pathogenesis. Highly conserved across mammalian species and widely expressed in human tissues, FSTL1 can be upregulated through signaling mediators of the innate immune system, such as TLR4 agonists and the arthritogenic cytokine IL-1beta via NFκB pathways, to stimulate the expression and secretion of pro-inflammatory cytokines, including TNF-alpha, IL-1beta, IL-6 and IL-8. While cells of mesenchymal lineage are capable of FSTL1 production, FSTL1 expression is notably absent from cells of hematopoietic lineage under normal physiological conditions. Macrophages and monocytes are, however, capable of taking up FSTL1 at sites of inflammation where FSTL1 stimulation can cause the expression of caspase-1 and its resultant enzymatic cleavage of active IL-1beta from pro-IL-1beta. Whereas the overexpression of FSTL1 has been noted as a substantial contributor to the progression of immune diseases like rheumatoid arthritis (RA) and osteoarthritis (OA), diminished FSTL1 serum levels have been identified as playing a significant part in both ovarian and endometrial carcinogenesis, where it directly affects cell proliferation, migration and invasion. The CHO cell-derived recombinant human FSTL1 is a 288-amino-acid-length glycoprotein with a calculated molecular weight of 32.7 kDa; however, due to glycosylation, protein migration occurs at an apparent molecular weight of approximately 50-55 kDa by SDS-PAGE analysis under both reducing and non-reducing conditions.

Follistatin Like Protein 1 (FSTL1) Antibody (FITC)
20-abx313312
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Follistatin Like Protein 1 (FSTL1) Antibody (FITC)
abx313312-100g 100 µg
EUR 362.5

Follistatin Like Protein 1 (FSTL1) Antibody (FITC)
abx313312-20g 20 µg
EUR 162.5

Follistatin Like Protein 1 (FSTL1) Antibody (FITC)
abx313312-50g 50 µg
EUR 250

Mouse Follistatin Like Protein 1 (FSTL1) Protein
abx690811-100ml 100 ml
EUR 325

Mouse Follistatin Like Protein 1 (FSTL1) Protein
abx690811-500ml 500 ml Ask for price

Mouse Follistatin Like Protein 1 (FSTL1) Protein
abx690811-50ml 50 ml
EUR 200

Mouse Follistatin Like Protein 1 (FSTL1) Protein
abx691348-100g 100 µg
EUR 200

Mouse Follistatin Like Protein 1 (FSTL1) Protein
abx691348-1mg 1 mg
EUR 325

Follistatin Like Protein 1 (FSTL1) Monoclonal Antibody (Human), FITC
4-MAJ085Hu21-FITC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Follistatin Like Protein 1 (FSTL1). This antibody is labeled with FITC.

Rat Follistatin Like Protein 1 ELISA kit
E02F0385-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Follistatin Like Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Follistatin Like Protein 1 ELISA kit
E02F0385-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Follistatin Like Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Follistatin Like Protein 1 ELISA kit
E02F0385-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Follistatin Like Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Follistatin Like Protein 1 ELISA kit
E07F0385-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Follistatin Like Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Follistatin Like Protein 1 ELISA kit
E07F0385-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Follistatin Like Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Follistatin Like Protein 1 ELISA kit
E07F0385-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Follistatin Like Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Follistatin Like Protein 1 ELISA kit
E08F0385-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Follistatin Like Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Follistatin Like Protein 1 ELISA kit
E08F0385-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Follistatin Like Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Follistatin Like Protein 1 ELISA kit
E08F0385-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Follistatin Like Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Follistatin Like Protein 1 ELISA kit
E01A13364 96T
EUR 700
Description: ELISA

Human FSTL3(Follistatin Like Protein 3) ELISA Kit
ELK9833-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human FSTL3. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human FSTL3. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human FSTL3, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human FSTL3 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human FSTL3(Follistatin Like Protein 3) ELISA Kit
ELK9833-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human FSTL3. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human FSTL3. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human FSTL3, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human FSTL3 in the samples is then determined by comparing the OD of the samples to the standard curve.

Monkey Follistatin Like Protein 1 (FSTL1) Protein
20-abx066684
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Monkey Follistatin Like Protein 1 (FSTL1) Protein
abx066684-100g 100 µg
EUR 750

Monkey Follistatin Like Protein 1 (FSTL1) Protein
abx066684-10g 10 µg
EUR 425

Monkey Follistatin Like Protein 1 (FSTL1) Protein
abx066684-50g 50 µg
EUR 612.5

Goat Follistatin Like Protein 1 ELISA kit
E01A48273 96T
EUR 700
Description: ELISA

Goat Follistatin Like Protein 1 ELISA kit
E06F0385-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat Follistatin Like Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Follistatin Like Protein 1 ELISA kit
E06F0385-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat Follistatin Like Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Follistatin Like Protein 1 ELISA kit
E06F0385-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat Follistatin Like Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Follistatin Like Protein 1 (FSTL1) Antibody (Biotin)
20-abx273428
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Follistatin Like Protein 1 (FSTL1) Antibody (Biotin)
20-abx273450
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Follistatin Like Protein 1 (FSTL1) Antibody (Biotin)
20-abx313313
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Follistatin Like Protein 1 (FSTL1) Antibody (Biotin)
abx273428-1g 1 g
EUR 387.5

Follistatin Like Protein 1 (FSTL1) Antibody (Biotin)
abx273428-5g 5 g
EUR 900

Follistatin Like Protein 1 (FSTL1) Antibody (Biotin)
abx273450-5mg 5 mg
EUR 1062.5

Follistatin Like Protein 1 (FSTL1) Antibody (Biotin)
abx313313-100g 100 µg
EUR 362.5

Follistatin Like Protein 1 (FSTL1) Antibody (Biotin)
abx313313-20g 20 µg
EUR 162.5
The intention of this evaluate is to explain recognized and rising actions of CMGC kinases that share the frequent property to phosphorylate SR proteins, in addition to their interaction with totally different households of viruses, in an effort to advance towards a complete data of their pro- or anti-viral phenotype and higher assess potential translational alternatives.

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