BACKGROUND Hepatic stellate cells (HSCs) play an important function in hepatic fibrogenesis. Our current scientific research indicated that the Zi Qi decoction, a Conventional Chinese language Drugs system, exhibited good efficacy in assuaging liver fibrosis, however the underlying mechanism stays elusive. MATERIAL AND METHODS Rats repeatedly injected with CCl₄ and cells stimulated with lipopolysaccharide had been used as in vivo and in vitro fashions for liver fibrosis, respectively.
The viability of LX-2 cells was evaluated with MTT assay. Relative messenger RNA (mRNA) expression of consultant extracellular matrix (ECM) parts was detected with real-time quantitative polymerase chain response (RT-qPCR). Furthermore, complete and phosphorylation ranges of ECM proteins and pathway-related proteins had been detected with western blotting. Immunofluorescent staining was used to point out the nuclear translocation of nuclear issue kappa b (NF-kappaB) p65.
Hematoxylin & eosin (H&E) and Masson trichrome staining and immunohistochemistry had been carried out to judge the extent of liver fibrosis. The degrees of alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyl transpeptidase (GGT), Hyp, tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) had been examined with an enzyme-linked immunosorbent assay. As well as, 7.0T micro-magnetic resonance imaging (micro-MRI) was used to judge the severity of hepatic injury.
RESULTS The Zi Qi decoction inhibited lipopolysaccharide-mediated upregulation of mRNA and protein ranges of consultant ECM proteins each in vivo and in vitro. The Zi Qi decoction additionally suppressed activation of the Toll-like receptor 4 (TLR4)-related NF-kappaB signaling pathway and subsequently inhibited the nuclear translocation of activated NF-kappaB. Furthermore, one other TLR4 downstream pathway, mitogen-activated protein kinase (MAPK), was concurrently restrained. The outcomes of liver pathology and MRI in rat fashions additionally steered the efficacy of the Zi Qi decoction in attenuating liver injury. CONCLUSIONS The Zi Qi decoction inhibited liver fibrosis by inhibiting the TLR4-related NF-kB and MAPK signaling pathways and stopping activation of HSCs.
Kinase-mediated RAS signaling by way of membraneless cytoplasmic protein granules
Receptor tyrosine kinase (RTK)-mediated activation of downstream effector pathways such because the RAS GTPase/MAP kinase (MAPK) signaling cascade is assumed to happen completely from lipid membrane compartments in mammalian cells. Right here, we uncover a membraneless, protein granule-based subcellular construction that may manage RTK/RAS/MAPK signaling in most cancers. Chimeric (fusion) oncoproteins involving sure RTKs together with ALK and RET bear de novo higher-order meeting into membraneless cytoplasmic protein granules that actively sign.
These pathogenic biomolecular condensates regionally focus the RAS activating complicated GRB2/SOS1 and activate RAS in a lipid membrane-independent method. RTK protein granule formation is vital for oncogenic RAS/MAPK signaling output in these cells. We establish a set of protein granule parts and set up structural guidelines that outline the formation of membraneless protein granules by RTK oncoproteins. Our findings reveal membraneless, higher-order cytoplasmic protein meeting as a definite subcellular platform for organizing oncogenic RTK and RAS signaling.
CDC2-like (CLK) protein kinase inhibition as a novel focused therapeutic technique in prostate most cancers
Dysregulation of other splicing is a function of most cancers, each in aetiology and development. It happens due to mutations in splice websites or websites that regulate splicing, or due to the altered expression and exercise of splice elements and of splice issue kinases that regulate splice issue exercise. Not too long ago the CDC2-like kinases (CLKs) have attracted consideration on account of their growing involvement in most cancers. We measured the impact of the CLK inhibitor, the benzothiazole TG003, on two prostate most cancers cell strains. TG003 decreased cell proliferation and elevated apoptosis in PC3 and DU145 cells.
Conversely, the overexpression of CLK1 in PC3 cells prevented TG003 from decreasing cell proliferation. TG003 slowed scratch closure and decreased cell migration and invasion in a transwell assay. TG003 decisively inhibited the expansion of a PC3 cell line xenograft in nude mice. We carried out a transcriptomic evaluation of cells handled with TG003. We report widespread and constant adjustments in various splicing of cancer-associated genes together with CENPE, ESCO2, CKAP2, MELK, ASPH and CD164 in each HeLa and PC3 cells. Collectively these findings counsel that concentrating on CLKs will present novel therapeutic alternatives in prostate most cancers.
Protein kinase A controls the hexosamine pathway by tuning the suggestions inhibition of GFAT-1
The hexosamine pathway (HP) is a key anabolic pathway whose product uridine 5′-diphospho-N-acetyl-D-glucosamine (UDP-GlcNAc) is a vital precursor for glycosylation processes in mammals. It modulates the ER stress response and HP activation extends lifespan in Caenorhabditis elegans. The extremely conserved glutamine fructose-6-phosphate amidotransferase 1 (GFAT-1) is the rate-limiting HP enzyme. GFAT-1 exercise is modulated by UDP-GlcNAc suggestions inhibition and by way of phosphorylation by protein kinase A (PKA). Molecular penalties of GFAT-1 phosphorylation, nevertheless, stay poorly understood.
Right here, we establish the GFAT-1 R203H substitution that elevates UDP-GlcNAc ranges in C. elegans. In human GFAT-1, the R203H substitution interferes with UDP-GlcNAc inhibition and with PKA-mediated Ser205 phosphorylation. Our knowledge point out that phosphorylation impacts the interactions of the 2 GFAT-1 domains to regulate catalytic exercise. Notably, Ser205 phosphorylation has two discernible results: it lowers baseline GFAT-1 exercise and abolishes UDP-GlcNAc suggestions inhibition. PKA controls the HP by uncoupling the metabolic suggestions loop of GFAT-1.
Modifications in expression of lysosomal membrane proteins in leucocytes of most cancers sufferers handled with tyrosine kinase inhibitors
Lysosomal sequestration of weak base medication has been recognized as one of many stress-related mechanisms that set off in vitro lysosomal biogenesis managed by transcription issue EB (TFEB). Whether or not such mechanism can induce lysosomal biogenesis in vivo is unknown. On this research, we addressed the query whether or not extended remedy with sunitinib (SUN) in sufferers with superior renal cell carcinoma (n = 22) and with imatinib (IM) in these with gastrointestinal stromal tumor (n = 6) might induce lysosomal biogenesis in leukocytes.
Lysosomal biogenesis was monitored utilizing immunoblotting of three lysosomal membrane proteins: lysosome-associated membrane proteins 1 and a couple of (LAMP1 and LAMP2) and vacuolar H+-ATPase, B2 subunit (ATP6V1B2). Current outcomes point out that extended remedy with SUN impacts LAMP1 and LAMP2 expression solely marginally in most sufferers. In distinction, adjustments in ATP6V1B2 expression had been marked and resembled irregular oscillations.
Mouse Angiopoietin Like Protein 3 ELISA kit |
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| E03A0506-48wellsplate | BlueGene | 48 wells plate | EUR 280 |
Mouse Angiopoietin Like Protein 3 ELISA kit |
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| E03A0506-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Mouse Angiopoietin Like Protein 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Angiopoietin Like Protein 3 ELISA kit |
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| E03A0506-96wellsplate | BlueGene | 96 wells plate | EUR 405 |
Mouse Angiopoietin Like Protein 3 ELISA Kit |
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| MBS032851-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6725 |
Mouse Angiopoietin Like Protein 3 ELISA Kit |
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| MBS032851-48StripWells | MyBiosource | 48-Strip-Wells | EUR 550 |
Mouse Angiopoietin Like Protein 3 ELISA Kit |
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| MBS032851-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3420 |
Mouse Angiopoietin Like Protein 3 ELISA Kit |
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| MBS032851-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
Mouse Angiopoietin Like Protein 3 ELISA Kit |
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| MBS723221-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 5685 |
Mouse Angiopoietin Like Protein 3 ELISA Kit |
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| MBS723221-48StripWells | MyBiosource | 48-Strip-Wells | EUR 485 |
Mouse Angiopoietin Like Protein 3 ELISA Kit |
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| MBS723221-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3020 |
Mouse Angiopoietin Like Protein 3 ELISA Kit |
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| MBS723221-96StripWells | MyBiosource | 96-Strip-Wells | EUR 690 |
Mouse Anti Human Angiopoietin Like Protein 3 Clone PAT23D8AT |
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| MBS147004-0005mg | MyBiosource | 0.005mg | EUR 240 |
Mouse Anti Human Angiopoietin Like Protein 3 Clone PAT23D8AT |
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| MBS147004-002mg | MyBiosource | 0.02mg | EUR 310 |
Mouse Anti Human Angiopoietin Like Protein 3 Clone PAT23D8AT |
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| MBS147004-01mg | MyBiosource | 0.1mg | EUR 610 |
Mouse Anti Human Angiopoietin Like Protein 3 Clone PAT23D8AT |
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| MBS147004-5x01mg | MyBiosource | 5x0.1mg | EUR 2405 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| DLR-ANGPTL3-Mu | DL Develop | 96T | EUR 302 |
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Description: serum, plasma, tissue homogenates or other biological fluids. |
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Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| DLR-ANGPTL3-Mu-48T | DL Develop | 48T | EUR 445.2 |
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Description: A sandwich quantitative ELISA assay kit for detection of Mouse Angiopoietin Like Protein 3 (ANGPTL3) in samples from serum, plasma, tissue homogenates or other biological fluids. |
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Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| DLR-ANGPTL3-Mu-96T | DL Develop | 96T | EUR 567.6 |
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Description: A sandwich quantitative ELISA assay kit for detection of Mouse Angiopoietin Like Protein 3 (ANGPTL3) in samples from serum, plasma, tissue homogenates or other biological fluids. |
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Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| abx518186-96tests | Abbexa | 96 tests | EUR 764.4 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| DL-ANGPTL3-Mu | DL Develop | 96T | EUR 287 |
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Description: serum, plasma, tissue homogenates or other biological fluids. |
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Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| EKN43483-48T | Biomatik Corporation | 48T | EUR 247.73 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| EKN43483-5x96T | Biomatik Corporation | 5x96T | EUR 1681.03 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| EKN43483-96T | Biomatik Corporation | 96T | EUR 353.9 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| EKU02372-48T | Biomatik Corporation | 48T | EUR 363.65 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| EKU02372-5x96T | Biomatik Corporation | 5x96T | EUR 2467.63 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| EKU02372-96T | Biomatik Corporation | 96T | EUR 519.5 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| EK12618 | SAB | 96Т | EUR 768 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| MBS450416-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3600 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| MBS450416-48StripWells | MyBiosource | 48-Strip-Wells | EUR 330 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| MBS450416-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 1845 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| MBS450416-96StripWells | MyBiosource | 96-Strip-Wells | EUR 420 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| MBS457620-10x96Tests | MyBiosource | 10x96Tests | EUR 3740 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| MBS457620-48Tests | MyBiosource | 48Tests | EUR 345 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| MBS457620-5x96Tests | MyBiosource | 5x96Tests | EUR 1915 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| MBS457620-96Tests | MyBiosource | 96Tests | EUR 435 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| MBS2024343-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3820 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| MBS2024343-24StripWells | MyBiosource | 24-Strip-Wells | EUR 285 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| MBS2024343-48StripWells | MyBiosource | 48-Strip-Wells | EUR 390 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| MBS2024343-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2075 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| MBS2024343-96StripWells | MyBiosource | 96-Strip-Wells | EUR 515 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| MBS2703619-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 2100 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| MBS2703619-24StripWells | MyBiosource | 24-Strip-Wells | EUR 220 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| MBS2703619-48StripWells | MyBiosource | 48-Strip-Wells | EUR 265 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| MBS2703619-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 1110 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| MBS2703619-96StripWells | MyBiosource | 96-Strip-Wells | EUR 320 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| MBS9307446-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6725 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| MBS9307446-48StripWells | MyBiosource | 48-Strip-Wells | EUR 550 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| MBS9307446-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3420 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| MBS9307446-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| SEB699Mu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 3549.37 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Angiopoietin Like Protein 3 (ANGPTL3) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| SEB699Mu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 397.48 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Angiopoietin Like Protein 3 (ANGPTL3) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| SEB699Mu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 516.4 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Angiopoietin Like Protein 3 (ANGPTL3) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| SEB699Mu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 1963.79 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Angiopoietin Like Protein 3 (ANGPTL3) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| 4-SEB699Mu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Angiopoietin Like Protein 3 (ANGPTL3) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. |
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Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| RD-ANGPTL3-Mu-48T | Reddot Biotech | 48T | EUR 309 |
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Description: sandwich |
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Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| RD-ANGPTL3-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 427.2 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| RD-ANGPTL3-Mu-96T | Reddot Biotech | 96T | EUR 441 |
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Description: sandwich |
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Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| RD-ANGPTL3-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 585.6 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| RDR-ANGPTL3-Mu-48T | Reddot Biotech | 48T | EUR 324 |
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Description: sandwich |
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Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| RDR-ANGPTL3-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 446.4 |
Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| RDR-ANGPTL3-Mu-96T | Reddot Biotech | 96T | EUR 463 |
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Description: sandwich |
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Mouse Angiopoietin Like Protein 3 (ANGPTL3) ELISA Kit |
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| RDR-ANGPTL3-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 612 |
Mouse ANGPTL3 (Angiopoietin Like Protein 3) ELISA Kit |
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| MBS2516112-10x96Tests | MyBiosource | 10x96Tests | EUR 4060 |
Mouse ANGPTL3 (Angiopoietin Like Protein 3) ELISA Kit |
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| MBS2516112-24Tests | MyBiosource | 24Tests | EUR 265 |
Mouse ANGPTL3 (Angiopoietin Like Protein 3) ELISA Kit |
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| MBS2516112-48Test | MyBiosource | 48Test | EUR 450 |
Mouse ANGPTL3 (Angiopoietin Like Protein 3) ELISA Kit |
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| MBS2516112-5x96Test | MyBiosource | 5x96Test | EUR 2265 |
Mouse ANGPTL3 (Angiopoietin Like Protein 3) ELISA Kit |
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| MBS2516112-96Tests | MyBiosource | 96Tests | EUR 535 |
Mouse ANGPTL3 (Angiopoietin Like Protein 3) ELISA Kit |
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| MBS8800330-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3130 |
Mouse ANGPTL3 (Angiopoietin Like Protein 3) ELISA Kit |
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| MBS8800330-48StripWells | MyBiosource | 48-Strip-Wells | EUR 315 |
Mouse ANGPTL3 (Angiopoietin Like Protein 3) ELISA Kit |
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| MBS8800330-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 1710 |
Mouse ANGPTL3 (Angiopoietin Like Protein 3) ELISA Kit |
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| MBS8800330-96StripWells | MyBiosource | 96-Strip-Wells | EUR 385 |
Mouse ANGPTL3(Angiopoietin Like Protein 3) ELISA Kit |
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| SYP-M0329-48wellsplate | UpingBio | 48 wells plate | EUR 180 |
Mouse ANGPTL3(Angiopoietin Like Protein 3) ELISA Kit |
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| SYP-M0329-96wellsplate | UpingBio | 96 wells plate | EUR 220 |
Mouse ANGPTL3(Angiopoietin Like Protein 3) ELISA Kit |
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| RE2893M-48wells | Reed Biotech | 48 wells | EUR 116.55 |
Mouse ANGPTL3(Angiopoietin Like Protein 3) ELISA Kit |
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| RE2893M-48wellsplate | Reed Biotech | 48-wells plate | EUR 126 |
Mouse ANGPTL3(Angiopoietin Like Protein 3) ELISA Kit |
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| RE2893M-96wells | Reed Biotech | 96 wells | EUR 161.55 |
Mouse ANGPTL3(Angiopoietin Like Protein 3) ELISA Kit |
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| RE2893M-96wellsplate | Reed Biotech | 96-wells plate | EUR 180 |
Mouse Angiopoietin Like Protein 3-ANGPTL3-ELISA kit |
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| QY-E20091 | Qayee Biotechnology | 96T | EUR 400 |
Mouse Angiopoietin Like Protein 3, ANGPTL3 GENLISA ELISA |
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| KLM1107 | Krishgen | 1 x 96 wells | EUR 341 |
Angiopoietin Like Protein 3 (ANGPTL3) Polyclonal Antibody (Mouse) |
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| 4-PAB699Mu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Angiopoietin Like Protein 3 (ANGPTL3) |
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Mouse Angiopoietin Like Protein 2 (ANGPTL2) Protein |
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| 20-abx065332 | Abbexa |
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Mouse Angiopoietin Like Protein 4 (ANGPTL4) Protein |
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| 20-abx065337 | Abbexa |
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Mouse Angiopoietin Like Protein 6 (ANGPTL6) Protein |
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| 20-abx065341 | Abbexa |
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Mouse Angiopoietin Like Protein 7 (ANGPTL7) Protein |
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| 20-abx065342 | Abbexa |
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Mouse Angiopoietin Like Protein 8 (ANGPTL8) Protein |
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| 20-abx165988 | Abbexa |
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Mouse Angiopoietin Like Protein 2 CLIA Kit |
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| MBS8426073-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse Angiopoietin Like Protein 4 CLIA Kit |
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| MBS8426074-INQUIRE | MyBiosource | INQUIRE | Ask for price |
ELISA kit for Mouse ANGPTL3 (Angiopoietin Like Protein 3) |
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| E-EL-M2458 | Elabscience Biotech | 1 plate of 96 wells | EUR 640.8 |
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Description: A sandwich ELISA kit for quantitative measurement of Mouse ANGPTL3 (Angiopoietin Like Protein 3) in samples from Serum, Plasma, Cell supernatant |
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ELISA kit for Mouse ANGPTL3 (Angiopoietin Like Protein 3) |
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| ELK1328 | ELK Biotech | 1 plate of 96 wells | EUR 446.4 |
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Description: A sandwich ELISA kit for detection of Angiopoietin Like Protein 3 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
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Mouse Angiopoietin Like Protein 1 ELISA kit |
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| E01A17712 | BlueGene | 96T | EUR 700 |
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Description: ELISA |
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Mouse Angiopoietin Like Protein 2 ELISA kit |
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| E01A17713 | BlueGene | 96T | EUR 700 |
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Description: ELISA |
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Mouse Angiopoietin Like Protein 4 ELISA kit |
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| E01A17715 | BlueGene | 96T | EUR 700 |
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Description: ELISA |
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Mouse Angiopoietin Like Protein 8 ELISA kit |
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| E01A19040 | BlueGene | 96T | EUR 700 |
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Description: ELISA |
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Mouse Angiopoietin Like Protein 1 ELISA kit |
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| E03A0504-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A sandwich ELISA for quantitative measurement of Mouse Angiopoietin Like Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Angiopoietin Like Protein 1 ELISA kit |
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| E03A0504-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A sandwich ELISA for quantitative measurement of Mouse Angiopoietin Like Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Angiopoietin Like Protein 1 ELISA kit |
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| E03A0504-48wellsplate | BlueGene | 48 wells plate | EUR 280 |
Mouse Angiopoietin Like Protein 1 ELISA kit |
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| E03A0504-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A sandwich ELISA for quantitative measurement of Mouse Angiopoietin Like Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Angiopoietin Like Protein 1 ELISA kit |
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| E03A0504-96wellsplate | BlueGene | 96 wells plate | EUR 405 |
Mouse Angiopoietin Like Protein 2 ELISA kit |
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| E03A0505-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Mouse Angiopoietin Like Protein 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Angiopoietin Like Protein 2 ELISA kit |
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| E03A0505-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Mouse Angiopoietin Like Protein 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Angiopoietin Like Protein 2 ELISA kit |
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| E03A0505-48wellsplate | BlueGene | 48 wells plate | EUR 280 |
Mouse Angiopoietin Like Protein 2 ELISA kit |
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| E03A0505-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Mouse Angiopoietin Like Protein 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Angiopoietin Like Protein 2 ELISA kit |
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| E03A0505-96wellsplate | BlueGene | 96 wells plate | EUR 405 |
Mouse Angiopoietin Like Protein 4 ELISA kit |
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| E03A0507-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Mouse Angiopoietin Like Protein 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Angiopoietin Like Protein 4 ELISA kit |
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| E03A0507-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Mouse Angiopoietin Like Protein 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Angiopoietin Like Protein 4 ELISA kit |
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| E03A0507-48wellsplate | BlueGene | 48 wells plate | EUR 280 |
Mouse Angiopoietin Like Protein 4 ELISA kit |
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| E03A0507-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Mouse Angiopoietin Like Protein 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Angiopoietin Like Protein 4 ELISA kit |
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| E03A0507-96wellsplate | BlueGene | 96 wells plate | EUR 405 |
Mouse Angiopoietin Like Protein 8 ELISA kit |
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| E03A4017-48wellsplate | BlueGene | 48 wells plate | EUR 280 |
Mouse Angiopoietin Like Protein 8 ELISA kit |
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| E03A4017-96wellsplate | BlueGene | 96 wells plate | EUR 405 |
Mouse Angiopoietin Like Protein 4 ELISA Kit |
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| IMSANGPTL4KT | Innovative research | each | EUR 718 |
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Description: Mouse Angiopoietin Like Protein 4 ELISA Kit |
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Mouse Angiopoietin Like Protein 8 ELISA Kit |
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| IMSANGPTL8KT | Innovative research | each | EUR 820 |
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Description: Mouse Angiopoietin Like Protein 8 ELISA Kit |
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Mouse Angiopoietin Like Protein 7 ELISA Kit |
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| MBS104306-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6725 |
Mouse Angiopoietin Like Protein 7 ELISA Kit |
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| MBS104306-48StripWells | MyBiosource | 48-Strip-Wells | EUR 550 |
Mouse Angiopoietin Like Protein 7 ELISA Kit |
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| MBS104306-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3420 |
Mouse Angiopoietin Like Protein 7 ELISA Kit |
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| MBS104306-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
Mouse Angiopoietin Like Protein 6 ELISA Kit |
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| MBS105960-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6725 |
Mouse Angiopoietin Like Protein 6 ELISA Kit |
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| MBS105960-48StripWells | MyBiosource | 48-Strip-Wells | EUR 550 |
Mouse Angiopoietin Like Protein 6 ELISA Kit |
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| MBS105960-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3420 |
Mouse Angiopoietin Like Protein 6 ELISA Kit |
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| MBS105960-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
Mouse Angiopoietin Like Protein 1 ELISA Kit |
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| MBS007907-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6725 |
Mouse Angiopoietin Like Protein 1 ELISA Kit |
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| MBS007907-48StripWells | MyBiosource | 48-Strip-Wells | EUR 550 |
Mouse Angiopoietin Like Protein 1 ELISA Kit |
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| MBS007907-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3420 |
Mouse Angiopoietin Like Protein 1 ELISA Kit |
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| MBS007907-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
Mouse Angiopoietin Like Protein 2 ELISA Kit |
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| MBS010342-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6725 |
Mouse Angiopoietin Like Protein 2 ELISA Kit |
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| MBS010342-48StripWells | MyBiosource | 48-Strip-Wells | EUR 550 |
Mouse Angiopoietin Like Protein 2 ELISA Kit |
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| MBS010342-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3420 |
Mouse Angiopoietin Like Protein 2 ELISA Kit |
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| MBS010342-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
Mouse Angiopoietin Like Protein 2 ELISA Kit |
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| MBS723121-48StripWellsCompetitive | MyBiosource | 48-Strip-Wells-(Competitive) | EUR 485 |
Mouse Angiopoietin Like Protein 2 ELISA Kit |
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| MBS723121-48StripWellsSandwich | MyBiosource | 48-Strip-Wells-(Sandwich) | EUR 485 |
Mouse Angiopoietin Like Protein 2 ELISA Kit |
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| MBS723121-5x96StripWellsCompetitive | MyBiosource | 5x96-Strip-Wells-(Competitive) | EUR 3020 |
Mouse Angiopoietin Like Protein 2 ELISA Kit |
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| MBS723121-96StripWellsCompetitive | MyBiosource | 96-Strip-Wells-(Competitive) | EUR 690 |
Mouse Angiopoietin Like Protein 2 ELISA Kit |
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| MBS723121-96StripWellsSandwich | MyBiosource | 96-Strip-Wells-(Sandwich) | EUR 690 |
Mouse Angiopoietin Like Protein 4 ELISA Kit |
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| MBS725085-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 5685 |
Mouse Angiopoietin Like Protein 4 ELISA Kit |
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| MBS725085-48StripWells | MyBiosource | 48-Strip-Wells | EUR 485 |
Mouse Angiopoietin Like Protein 4 ELISA Kit |
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| MBS725085-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3020 |
Mouse Angiopoietin Like Protein 4 ELISA Kit |
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| MBS725085-96StripWells | MyBiosource | 96-Strip-Wells | EUR 690 |
Mouse Angiopoietin Like Protein 2 ELISA Kit |
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| MBS761776-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3900 |
Mouse Angiopoietin Like Protein 2 ELISA Kit |
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| MBS761776-48StripWells | MyBiosource | 48-Strip-Wells | EUR 340 |
Mouse Angiopoietin Like Protein 2 ELISA Kit |
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| MBS761776-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2045 |
Mouse Angiopoietin Like Protein 2 ELISA Kit |
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| MBS761776-96StripWells | MyBiosource | 96-Strip-Wells | EUR 455 |
Mouse Angiopoietin Like Protein 4 ELISA Kit |
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| MBS763448-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3900 |
Mouse Angiopoietin Like Protein 4 ELISA Kit |
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| MBS763448-48StripWells | MyBiosource | 48-Strip-Wells | EUR 340 |
Mouse Angiopoietin Like Protein 4 ELISA Kit |
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| MBS763448-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2045 |
Mouse Angiopoietin Like Protein 4 ELISA Kit |
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| MBS763448-96StripWells | MyBiosource | 96-Strip-Wells | EUR 455 |
Mouse Angiopoietin Like Protein 1 ELISA Kit |
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| MBS730831-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 5685 |
Mouse Angiopoietin Like Protein 1 ELISA Kit |
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| MBS730831-48StripWells | MyBiosource | 48-Strip-Wells | EUR 485 |
Mouse Angiopoietin Like Protein 1 ELISA Kit |
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| MBS730831-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3020 |
Mouse Angiopoietin Like Protein 1 ELISA Kit |
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| MBS730831-96StripWells | MyBiosource | 96-Strip-Wells | EUR 690 |
Mouse Angiopoietin Like Protein 8 ELISA Kit |
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| MBS7269754-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 5685 |
Mouse Angiopoietin Like Protein 8 ELISA Kit |
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| MBS7269754-48StripWells | MyBiosource | 48-Strip-Wells | EUR 485 |
Mouse Angiopoietin Like Protein 8 ELISA Kit |
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| MBS7269754-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3020 |
Mouse Angiopoietin Like Protein 8 ELISA Kit |
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| MBS7269754-96StripWells | MyBiosource | 96-Strip-Wells | EUR 690 |
EasyPro Mouse Angiopoietin Like Protein 3(ANGPTL3)ELISA Kit |
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| FY-EM2893S | Feiyuebio | each | EUR 520 |
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Description: 0.1 ng/mL |
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Angiopoietin Like Protein 3 (ANGPTL3) Polyclonal Antibody (Mouse), PE |
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| 4-PAB699Mu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Angiopoietin Like Protein 3 (ANGPTL3). This antibody is labeled with PE. |
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Mouse Angiopoietin Like Protein 4 (ANGPTL4) ELISA |
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| KT-32311 | Kamiya Biomedical Company | 96 tests | EUR 977 |
Angiopoietin Like Protein 3 (ANGPTL3) Polyclonal Antibody (Mouse), APC |
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| 4-PAB699Mu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Angiopoietin Like Protein 3 (ANGPTL3). This antibody is labeled with APC. |
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Angiopoietin Like Protein 3 (ANGPTL3) Polyclonal Antibody (Mouse), Cy3 |
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| 4-PAB699Mu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Angiopoietin Like Protein 3 (ANGPTL3). This antibody is labeled with Cy3. |
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Angiopoietin Like Protein 3 (ANGPTL3) Polyclonal Antibody (Mouse), FITC |
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| 4-PAB699Mu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Angiopoietin Like Protein 3 (ANGPTL3). This antibody is labeled with FITC. |
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Angiopoietin Like Protein 3 (ANGPTL3) Polyclonal Antibody (Mouse), HRP |
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| 4-PAB699Mu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Angiopoietin Like Protein 3 (ANGPTL3). This antibody is labeled with HRP. |
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Uncoated Mouse ANGPTL3 (Angiopoietin Like Protein 3) ELISA Kit |
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| MBS2571848-15x96Tests3xMBS2571967AncillaryKit | MyBiosource | 15x96Tests+3xMBS2571967(AncillaryKit) | EUR 1565 |
Uncoated Mouse ANGPTL3 (Angiopoietin Like Protein 3) ELISA Kit |
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| MBS2571848-5x96TestsMBS2571967AncillaryKit | MyBiosource | 5x96Tests+MBS2571967(AncillaryKit) | EUR 670 |
Angiopoietin Like Protein 3 (ANGPTL3) Polyclonal Antibody (Human, Mouse) |
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| 4-PAB699Mu02 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Mouse Angiopoietin Like Protein 3 (ANGPTL3) |
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Mouse ANGPTL2 -Angiopoietin Like Protein 2- CLIA Kit |
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| E-CL-M0079-24Tests | Elabscience Biotech | 24 Tests | EUR 180 |
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Description: Sandwich |
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Mouse ANGPTL2 -Angiopoietin Like Protein 2- CLIA Kit |
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| E-CL-M0079-48Tests | Elabscience Biotech | 48 Tests | EUR 546 |
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Description: Sandwich |
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Mouse ANGPTL2 -Angiopoietin Like Protein 2- CLIA Kit |
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| E-CL-M0079-96Tests | Elabscience Biotech | 96 Tests | EUR 682 |
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Description: Sandwich |
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Mouse ANGPTL2 -Angiopoietin Like Protein 2- CLIA Kit |
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| E-CL-M0079-96Tests10 | Elabscience Biotech | 96 Tests *10 | EUR 6820 |
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Description: Sandwich |
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Mouse ANGPTL2 -Angiopoietin Like Protein 2- CLIA Kit |
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| E-CL-M0079-96Tests5 | Elabscience Biotech | 96 Tests *5 | EUR 3410 |
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Description: Sandwich |
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Mouse ANGPTL4 -Angiopoietin Like Protein 4- CLIA Kit |
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| E-CL-M0080-24Tests | Elabscience Biotech | 24 Tests | EUR 180 |
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Description: Sandwich |
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Mouse ANGPTL4 -Angiopoietin Like Protein 4- CLIA Kit |
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| E-CL-M0080-48Tests | Elabscience Biotech | 48 Tests | EUR 546 |
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Description: Sandwich |
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Mouse ANGPTL4 -Angiopoietin Like Protein 4- CLIA Kit |
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| E-CL-M0080-96Tests | Elabscience Biotech | 96 Tests | EUR 682 |
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Description: Sandwich |
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Mouse ANGPTL4 -Angiopoietin Like Protein 4- CLIA Kit |
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| E-CL-M0080-96Tests10 | Elabscience Biotech | 96 Tests *10 | EUR 6820 |
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Description: Sandwich |
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Mouse ANGPTL4 -Angiopoietin Like Protein 4- CLIA Kit |
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| E-CL-M0080-96Tests5 | Elabscience Biotech | 96 Tests *5 | EUR 3410 |
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Description: Sandwich |
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Mouse ANGPTL2 (Angiopoietin Like Protein 2) CLIA Kit |
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| MBS2532065-5x96Tests | MyBiosource | 5x96Tests | EUR 2565 |
Mouse ANGPTL2 (Angiopoietin Like Protein 2) CLIA Kit |
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| MBS2532065-96Tests | MyBiosource | 96Tests | EUR 560 |
Mouse ANGPTL4 (Angiopoietin Like Protein 4) CLIA Kit |
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| MBS2533224-5x96Tests | MyBiosource | 5x96Tests | EUR 2565 |
Mouse ANGPTL4 (Angiopoietin Like Protein 4) CLIA Kit |
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| MBS2533224-96Tests | MyBiosource | 96Tests | EUR 560 |
Mouse Angiopoietin Like Protein 7 (ANGPTL7) ELISA Kit |
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| abx572497-96tests | Abbexa | 96 tests | EUR 886.8 |
Mouse Angiopoietin Like Protein 2 (ANGPTL2) ELISA Kit |
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| abx575925-96tests | Abbexa | 96 tests | EUR 999.6 |
Mouse Angiopoietin Like Protein 2 (ANGPTL2) ELISA Kit |
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| DLR-ANGPTL2-Mu | DL Develop | 96T | EUR 454 |
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Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Mouse Angiopoietin Like Protein 2 (ANGPTL2) ELISA Kit |
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| DLR-ANGPTL2-Mu-48T | DL Develop | 48T | EUR 609.6 |
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Description: A sandwich quantitative ELISA assay kit for detection of Mouse Angiopoietin Like Protein 2 (ANGPTL2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Mouse Angiopoietin Like Protein 2 (ANGPTL2) ELISA Kit |
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| DLR-ANGPTL2-Mu-96T | DL Develop | 96T | EUR 793.2 |
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Description: A sandwich quantitative ELISA assay kit for detection of Mouse Angiopoietin Like Protein 2 (ANGPTL2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Mouse Angiopoietin Like Protein 4 (ANGPTL4) ELISA Kit |
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| DLR-ANGPTL4-Mu | DL Develop | 96T | EUR 454 |
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Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Mouse Angiopoietin Like Protein 4 (ANGPTL4) ELISA Kit |
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| DLR-ANGPTL4-Mu-48T | DL Develop | 48T | EUR 609.6 |
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Description: A sandwich quantitative ELISA assay kit for detection of Mouse Angiopoietin Like Protein 4 (ANGPTL4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Mouse Angiopoietin Like Protein 4 (ANGPTL4) ELISA Kit |
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| DLR-ANGPTL4-Mu-96T | DL Develop | 96T | EUR 793.2 |
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Description: A sandwich quantitative ELISA assay kit for detection of Mouse Angiopoietin Like Protein 4 (ANGPTL4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Mouse Angiopoietin Like Protein 7 (ANGPTL7) ELISA Kit |
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| DLR-ANGPTL7-Mu | DL Develop | 96T | EUR 518 |
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Description: serum, plasma, tissue homogenates or other biological fluids. |
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Mouse Angiopoietin Like Protein 7 (ANGPTL7) ELISA Kit |
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| DLR-ANGPTL7-Mu-48T | DL Develop | 48T | EUR 679.2 |
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Description: A sandwich quantitative ELISA assay kit for detection of Mouse Angiopoietin Like Protein 7 (ANGPTL7) in samples from serum, plasma, tissue homogenates or other biological fluids. |
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Mouse Angiopoietin Like Protein 7 (ANGPTL7) ELISA Kit |
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| DLR-ANGPTL7-Mu-96T | DL Develop | 96T | EUR 889.2 |
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Description: A sandwich quantitative ELISA assay kit for detection of Mouse Angiopoietin Like Protein 7 (ANGPTL7) in samples from serum, plasma, tissue homogenates or other biological fluids. |
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Mouse Angiopoietin Like Protein 8 (ANGPTL8) ELISA Kit |
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| DLR-ANGPTL8-Mu | DL Develop | 96T | EUR 518 |
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Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Mouse Angiopoietin Like Protein 8 (ANGPTL8) ELISA Kit |
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| DLR-ANGPTL8-Mu-48T | DL Develop | 48T | EUR 679.2 |
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Description: A sandwich quantitative ELISA assay kit for detection of Mouse Angiopoietin Like Protein 8 (ANGPTL8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Mouse Angiopoietin Like Protein 8 (ANGPTL8) ELISA Kit |
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| DLR-ANGPTL8-Mu-96T | DL Develop | 96T | EUR 889.2 |
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Description: A sandwich quantitative ELISA assay kit for detection of Mouse Angiopoietin Like Protein 8 (ANGPTL8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Mouse Angiopoietin Like Protein 8 (ANGPTL8) ELISA Kit |
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| abx254887-96tests | Abbexa | 96 tests | EUR 886.8 |
Mouse Angiopoietin Like Protein 6,ANGPTL6 ELISA KIT |
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| E0826Mo-1096T | Jiaxing Korain Biotech Ltd (BT Labs) | 10*96T | EUR 4122 |
Mouse Angiopoietin Like Protein 6,ANGPTL6 ELISA KIT |
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| E0826Mo-48wells | Jiaxing Korain Biotech Ltd (BT Labs) | 48 wells | EUR 300 |
Mouse Angiopoietin Like Protein 6,ANGPTL6 ELISA KIT |
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| E0826Mo-596T | Jiaxing Korain Biotech Ltd (BT Labs) | 5*96T | EUR 2061 |
Mouse Angiopoietin Like Protein 6,ANGPTL6 ELISA KIT |
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| E0826Mo-96wells | Jiaxing Korain Biotech Ltd (BT Labs) | 96 wells | EUR 458 |
Very comparable adjustments within the expression of lysosomal membrane proteins had been additionally present in IM-treated sufferers. Conclusion: extended remedy of most cancers sufferers with SUN and IM didn’t induce leucocyte lysosomal biogenesis however dramatically affected expression of ATP6V1B2.